多模式信息在医疗任务中经常可用。通过结合来自多个来源的信息，临床医生可以做出更准确的判断。近年来，在临床实践中使用了多种成像技术进行视网膜分析：2D眼底照片，3D光学相干断层扫描（OCT）和3D OCT血管造影等。我们的论文研究了基于深度学习的三种多模式信息融合策略，以求解视网膜视网膜分析任务：早期融合，中间融合和分层融合。常用的早期和中间融合很简单，但不能完全利用模式之间的互补信息。我们开发了一种分层融合方法，该方法着重于将网络多个维度的特征组合在一起，并探索模式之间的相关性。这些方法分别用于使用公共伽马数据集（Felcus Photophs和OCT）以及Plexelite 9000（Carl Zeis Meditec Inc.）的私人数据集，将这些方法应用于青光眼和糖尿病性视网膜病变分类。我们的分层融合方法在病例中表现最好，并为更好的临床诊断铺平了道路。

纵向成像能够捕获静态解剖结构和疾病进展的动态变化，向早期和更好的患者特异性病理学管理。但是，检测糖尿病性视网膜病（DR）的常规方法很少利用纵向信息来改善DR分析。在这项工作中，我们调查了利用纵向诊断目的的纵向性质利用自我监督学习的好处。我们比较了不同的纵向自学学习（LSSL）方法，以模拟从纵向视网膜颜色眼底照片（CFP）进行疾病进展，以便使用一对连续考试来检测早期的DR严重性变化。实验是在有或没有那些经过训练的编码器（LSSL）的纵向DR筛选数据集上进行的，该数据集充当纵向借口任务。结果对于基线（从头开始训练）的AUC为0.875，AUC为0.96（95％CI：0.9593-0.9655 DELONG测试），使用p值<2.2e-16，在早期融合上使用简单的重置式结构，使用冷冻的LSSL重量，这表明LSSL潜在空间可以编码DR进程的动态。

用于计算病理（CPATH）的深度分割模型的发展可以帮助培养可解释的形态生物标志物的调查。然而，这些方法的成功存在主要瓶颈，因为监督的深度学习模型需要丰富的准确标记数据。该问题在CPATH领域加剧，因为详细注释的产生通常需要对病理学家的输入能够区分不同的组织构建体和核。手动标记核可能不是收集大规模注释数据集的可行方法，特别是当单个图像区域可以包含数千个不同的单元时。但是，仅依靠自动生成注释将限制地面真理的准确性和可靠性。因此，为了帮助克服上述挑战，我们提出了一种多级注释管道，以使大规模数据集进行用于组织学图像分析，具有病理学家in-循环的细化步骤。使用本市管道，我们生成最大的已知核实例分段和分类数据集，其中包含近百万分之一的H＆E染色的结肠组织中标记的细胞核。我们发布了DataSet并鼓励研究社区利用它来推动CPATH中下游小区模型的发展。

Non-linear state-space models, also known as general hidden Markov models, are ubiquitous in statistical machine learning, being the most classical generative models for serial data and sequences in general. The particle-based, rapid incremental smoother PaRIS is a sequential Monte Carlo (SMC) technique allowing for efficient online approximation of expectations of additive functionals under the smoothing distribution in these models. Such expectations appear naturally in several learning contexts, such as likelihood estimation (MLE) and Markov score climbing (MSC). PARIS has linear computational complexity, limited memory requirements and comes with non-asymptotic bounds, convergence results and stability guarantees. Still, being based on self-normalised importance sampling, the PaRIS estimator is biased. Our first contribution is to design a novel additive smoothing algorithm, the Parisian particle Gibbs PPG sampler, which can be viewed as a PaRIS algorithm driven by conditional SMC moves, resulting in bias-reduced estimates of the targeted quantities. We substantiate the PPG algorithm with theoretical results, including new bounds on bias and variance as well as deviation inequalities. Our second contribution is to apply PPG in a learning framework, covering MLE and MSC as special examples. In this context, we establish, under standard assumptions, non-asymptotic bounds highlighting the value of bias reduction and the implicit Rao--Blackwellization of PPG. These are the first non-asymptotic results of this kind in this setting. We illustrate our theoretical results with numerical experiments supporting our claims.

In recent years, social media has been widely explored as a potential source of communication and information in disasters and emergency situations. Several interesting works and case studies of disaster analytics exploring different aspects of natural disasters have been already conducted. Along with the great potential, disaster analytics comes with several challenges mainly due to the nature of social media content. In this paper, we explore one such challenge and propose a text classification framework to deal with Twitter noisy data. More specifically, we employed several transformers both individually and in combination, so as to differentiate between relevant and non-relevant Twitter posts, achieving the highest F1-score of 0.87.

Nowadays, the current neural network models of dialogue generation(chatbots) show great promise for generating answers for chatty agents. But they are short-sighted in that they predict utterances one at a time while disregarding their impact on future outcomes. Modelling a dialogue's future direction is critical for generating coherent, interesting dialogues, a need that has led traditional NLP dialogue models that rely on reinforcement learning. In this article, we explain how to combine these objectives by using deep reinforcement learning to predict future rewards in chatbot dialogue. The model simulates conversations between two virtual agents, with policy gradient methods used to reward sequences that exhibit three useful conversational characteristics: the flow of informality, coherence, and simplicity of response (related to forward-looking function). We assess our model based on its diversity, length, and complexity with regard to humans. In dialogue simulation, evaluations demonstrated that the proposed model generates more interactive responses and encourages a more sustained successful conversation. This work commemorates a preliminary step toward developing a neural conversational model based on the long-term success of dialogues.

Three-dimensional (3D) technologies have been developing rapidly recent years, and have influenced industrial, medical, cultural, and many other fields. In this paper, we introduce an automatic 3D human head scanning-printing system, which provides a complete pipeline to scan, reconstruct, select, and finally print out physical 3D human heads. To enhance the accuracy of our system, we developed a consumer-grade composite sensor (including a gyroscope, an accelerometer, a digital compass, and a Kinect v2 depth sensor) as our sensing device. This sensing device is then mounted on a robot, which automatically rotates around the human subject with approximate 1-meter radius, to capture the full-view information. The data streams are further processed and fused into a 3D model of the subject using a tablet located on the robot. In addition, an automatic selection method, based on our specific system configurations, is proposed to select the head portion. We evaluated the accuracy of the proposed system by comparing our generated 3D head models, from both standard human head model and real human subjects, with the ones reconstructed from FastSCAN and Cyberware commercial laser scanning systems through computing and visualizing Hausdorff distances. Computational cost is also provided to further assess our proposed system.

We propose a 6D RGB-D odometry approach that finds the relative camera pose between consecutive RGB-D frames by keypoint extraction and feature matching both on the RGB and depth image planes. Furthermore, we feed the estimated pose to the highly accurate KinectFusion algorithm, which uses a fast ICP (Iterative Closest Point) to fine-tune the frame-to-frame relative pose and fuse the depth data into a global implicit surface. We evaluate our method on a publicly available RGB-D SLAM benchmark dataset by Sturm et al. The experimental results show that our proposed reconstruction method solely based on visual odometry and KinectFusion outperforms the state-of-the-art RGB-D SLAM system accuracy. Moreover, our algorithm outputs a ready-to-use polygon mesh (highly suitable for creating 3D virtual worlds) without any postprocessing steps.

In this paper, a Kinect-based distributed and real-time motion capture system is developed. A trigonometric method is applied to calculate the relative position of Kinect v2 sensors with a calibration wand and register the sensors' positions automatically. By combining results from multiple sensors with a nonlinear least square method, the accuracy of the motion capture is optimized. Moreover, to exclude inaccurate results from sensors, a computational geometry is applied in the occlusion approach, which discovers occluded joint data. The synchronization approach is based on an NTP protocol that synchronizes the time between the clocks of a server and clients dynamically, ensuring that the proposed system is a real-time system. Experiments for validating the proposed system are conducted from the perspective of calibration, occlusion, accuracy, and efficiency. Furthermore, to demonstrate the practical performance of our system, a comparison of previously developed motion capture systems (the linear trilateration approach and the geometric trilateration approach) with the benchmark OptiTrack system is conducted, therein showing that the accuracy of our proposed system is $38.3\%$ and 24.1% better than the two aforementioned trilateration systems, respectively.

With the increase in health consciousness, noninvasive body monitoring has aroused interest among researchers. As one of the most important pieces of physiological information, researchers have remotely estimated the heart rate (HR) from facial videos in recent years. Although progress has been made over the past few years, there are still some limitations, like the processing time increasing with accuracy and the lack of comprehensive and challenging datasets for use and comparison. Recently, it was shown that HR information can be extracted from facial videos by spatial decomposition and temporal filtering. Inspired by this, a new framework is introduced in this paper to remotely estimate the HR under realistic conditions by combining spatial and temporal filtering and a convolutional neural network. Our proposed approach shows better performance compared with the benchmark on the MMSE-HR dataset in terms of both the average HR estimation and short-time HR estimation. High consistency in short-time HR estimation is observed between our method and the ground truth.